This project will be a consortium of center grants and individual investigator grants to study the neurologic aspects of aging in Macaca mulattas. The University of Puerto Rico will provide the facilities of the Caribbean Primate Research Center and investigators in behavioral research at Cayo Santiago and Sabana Seca. Investigators with individual research projects from the University of Puerto Rico and the Veterans Administration Hospital in San Juan will use the primate facilities. Dr. Price and his colleagues at Johns Hopkins University will map neurotransmitter pathways in the young, adult, and aging primate brain. OBFS will provide the computer facility and a statistical coordinating center to process the data and to collaborate on identifying associations across individual project boundaries.